Authors: CHOI, D. K.¹; CHIN, J. H.¹; LEE, E. H.¹; LIM, O. B.²; CHUNG, C. H.²; RO, Y. J.¹; CHOI, I. C.¹

Source: Acta Anaesthesiologica Scandinavica, Volume 54, Number 8, September 2010 , pp. 962-969(8)

Publisher: Wiley-Blackwell

Abstract:

Background:

The aim of this study was to evaluate the efficacy of ondansetron and ramosetron in the reduction of post-operative nausea and vomiting (PONV) associated with patient-controlled analgesia (PCA) after cardiac surgery. Methods:

A total of 320 patients scheduled for elective cardiac surgery were enrolled. Patients were randomly assigned to one of four treatment regimens (n=80 in each group): no prophylactic antiemetics (group P); intravenous (i.v.) ondansetron 4 mg at the end of surgery and 12 mg added to PCA (group O); i.v. ramosetron 0.3 mg at the end of surgery and no antiemetics added to PCA (group R1); and i.v. ramosetron 0.3 mg at the end of surgery and 0.6 mg added to PCA (group R2). Results:

The incidence of PONV during the 48-h post-operative period was lower in groups O (46%), R1 (54%), and R2 (35%) compared with group P (71%, P<0.001). The incidence and severity of nausea were lower in groups O, R1, and R2 than in group P during the 24-h post-operative period, whereas the incidence and severity of nausea during 24-48 h after surgery were lower in groups O and R2, but not in group R1, than in group P. Compared with group P (53%), the frequency of rescue antiemetic usage was significantly lower in groups O (34%) and R2 (29%), but not in group R1 (43%). Conclusion:

The addition of either ondansetron or ramosetron to PCA can reduce the incidence of PONV during 48 h after cardiac surgery.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-6576.2010.02275.x

Affiliations: 1: Anesthesiology and Pain Medicine 2: Cardiovascular Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea

Publication date: 2010-09-01

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