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Global and right ventricular end-diastolic volumes correlate better with preload after correction for ejection fraction

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Volumetric monitoring with right ventricular end-diastolic volume indexed (RVEDVi) and global end-diastolic volume indexed (GEDVi) is increasingly being suggested as a superior preload indicator compared with the filling pressures central venous pressure (CVP) or the pulmonary capillary wedge pressure (PCWP). However, static monitoring of these volumetric parameters has not consistently been shown to be able to predict changes in cardiac index (CI). The aim of this study was to evaluate whether a correction of RVEDVi and GEDVi with a measure of the individual contractile reserve, assessed by right ventricular ejection fraction (RVEF) and global ejection fraction, improves the ability of RVEDVi and GEDVi to monitor changes in preload over time in critically ill patients. Methods:

Hemodynamic measurements, both by pulmonary artery and by transcardiopulmonary thermodilution, were performed in 11 mechanically ventilated medical ICU patients. Correction of volumes was achieved by normalization to EF deviation from normal EF values in an exponential fashion. Data before and after fluid administration were obtained in eight patients, while data before and after diuretics were obtained in seven patients. Results:

No correlation was found between the change in cardiac filling pressures (ΔCVP, ΔPCWP) and ΔCI (R2 0.01 and 0.00, respectively). Further, no correlation was found between ΔRVEDVi or ΔGEDVi and ΔCI (R2 0.10 and 0.13, respectively). In contrast, a significant correlation was found between ΔRVEDVi corrected to RVEF (ΔcRVEDVi) and ΔCI (R2 0.64), as well as between ΔcGEDVi and ΔCI (R2 0.59). An increase in the net fluid balance with +844 ± 495 ml/m2 resulted in a significant increase in CI of 0.5 ± 0.3 l/min/m2; however, only ΔcRVEDVi (R2 0.58) and ΔcGEDVi (R2 0.36) correlated significantly with ΔCI. Administration of diuretics resulting in a net fluid balance of −942 ± 658 ml/m2 caused a significant decrease in CI with 0.7 ± 0.5 l/min/m2; however, only ΔcRVEDVi (R2 0.80) and ΔcGEDVi (R2 0.61) correlated significantly with ΔCI. Conclusion:

Correction of volumetric preload parameters by measures of ejection fraction improved the ability of these parameters to assess changes in preload over time in this heterogeneous group of critically ill patients.

Document Type: Research Article


Affiliations: 1: Department of Intensive Care Medicine, ZNA Stuivenberg, Antwerpen, Belgium 2: Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, Hamburg-Eppendorf University Hospital, Hamburg, Germany

Publication date: 2010-05-01

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