Authors: YIN, Q.-Q.¹; WU, L.¹; GOU, M.-L.²; QIAN, Z.-Y.²; ZHANG, W.-S.¹; LIU, J.¹

Source: Acta Anaesthesiologica Scandinavica, Volume 53, Number 9, October 2009 , pp. 1207-1213(7)

Publisher: Wiley-Blackwell

Abstract:

Background:

Infiltration of a long-lasting anaesthetic is helpful during the post-operative period. The recently developed local drug delivery system, biodegradable nanoparticles in a thermo-sensitive hydrogel (nanogel system), may possibly provide an extended duration of drugs. Therefore, we evaluated whether prolonged infiltration anaesthesia could be achieved by loading lidocaine into this delivery system. Methods:

Thirty male rats were randomized into five groups of six rats each: saline; 2% hydrochloride lidocaine solution; lidocaine-loaded nanogel system and its compositing formulations, namely lido-nano gel; lido-nano; and lidogel. Durations of local anaesthesia with subcutaneously injected agents were measured by tail flick latency tests in a randomized, blind fashion. Results:

Lido-nano gel produced effective anaesthesia for 360±113 min, compared with 150±33 min by lidogel, 180±37 min by lido-nano, and 110±45 min by lidocaine solution (P<0.001, means±SD), and elicited complete sensory blockade for 300±114 min, compared with 75±37 min by lidogel, 105±53 min by lido-nano, and 60±33 min by lidocaine solution (P<0.001, means±SD) without severe skin/systemic toxicity. Conclusion:

Lidocaine-loaded biodegradable nanoparticles in hydrogel produced prolonged infiltration anaesthesia in rats without severe toxicity, indicating a possible way to develop long-lasting local anaesthetics.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-6576.2009.02030.x

Affiliations: 1: Laboratory of Anaesthesiology and Critical Care Medicine, Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu, China 2: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China

Publication date: 2009-10-01

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