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Fentanyl-induced cough does not depend on injection speed: a randomized study

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The aim of the study was to investigate whether the incidence of cough after intravenous fentanyl depends on the speed of injection. Methods:

With ethics committee approval, 476 ASA class I–III nonsmoking patients free of bronchial hyperreactivity and respiratory tract infection undergoing general anaesthesia for elective surgery were randomized to either 1.5 g/kg fentanyl injected over 2, 5 or 10 s or placebo (saline) via a periphereal intravenous cannula. The primary endpoint was the incidence of cough within 5 min after completion of injection. Results:

The study was terminated for futility after enrollment of 476 patients because an interim analysis yielded an incidence of cough of 3%, 3% and 6% in the three fentanyl groups, respectively, and of 2% in the placebo group, with no difference between groups (P=0.374, 2 test for cough between fentanyl and placebo groups). Conclusions:

Under the conditions of our study, the incidence of cough after 1.5 g/kg fentanyl injected intravenously over 2, 5 or 10 s was between 3% and 6%, unrelated to the speed of injection and not different from placebo.

Document Type: Research Article


Affiliations: Department of Anaesthesia and Perioperative Medicine, Asklepios Klinik Langen, Langen, Academic Teaching Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Frankfurt, Germany

Publication date: September 1, 2008


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