If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Effect of fentanyl on heart rate variability during spontaneous and paced breathing in healthy volunteers

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Background:

Many studies have been conducted to assess the effects of fentanyl on the autonomic nervous system (ANS) by heart rate variability (HRV) analysis, but disagreement on the results is still present due to confounding influences introduced by concomitant administration of other drugs or opioid-related transitory respiratory depression. We performed a single-drug controlled-breathing study on healthy volunteers to assess the impact of fentanyl on ANS. Methods:

HRV as a measure of sympathovagal balance was prospectively analyzed with an autoregressive model in 11 subjects during spontaneous and paced breathing (PB) at 20 breaths/min both before and after fentanyl 1 mcg/kg administration. HRV total power, sympathovagal balance (low-frequency/high-frequency ratio) and normalized spectral powers were considered (LFnu, HFnu). Results:

Fentanyl led to a reduction of LFnu (from 55.2±23.3 to 43.2±24.1, P<0.05) without HFnu increase during PB. A decrease in RR interval variance (from 3345.6±3333.4 to 1806.9±1328.6 ms2, P<0.05) was shown after fentanyl administration during spontaneous but not PB. PB alone decreased the HRV total power and RR interval variance. Conclusions:

Low-dose fentanyl administration in healthy volunteers leads to sympathetic and overall ANS modulation decrease, with a trend toward vagal activation.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1399-6576.2008.01713.x

Affiliations: Intensive Care Unit Department, Luigi Sacco University Hospital of Milan, Milano, Italy

Publication date: September 1, 2008

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more