Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema

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Abstract:

Background: 

Prostacyclin (PGI2) and its stable analogues are known to reduce capillary hydraulic permeability. This study explores the biochemical and physiological effects of i.v. infusion of low-dose PGI2 in an experimental model of vasogenic brain oedema. Methods: 

Twenty-seven anaesthetized and mechanically ventilated piglets with brain oedema induced by intrathecal injection of lipopolysaccharide (LPS) were used. Five of the animals received a continuous infusion of PGI2 (1 ng kg−1 min−1) i.v. Four microdialysis catheters were placed in the brain to measure interstitial concentrations of glucose, lactate, and glycerol. Mean arterial pressure (MAP), intracranial pressure (ICP) and temperature were monitored continuously. Low-dose infusion of PGI2 started 1 h before the LPS injection and was constant during the study period. Results: 

Intracranial pressure increased significantly in animals treated with PGI2. The increase in ICP was associated with significant cerebral biochemical changes: decrease in glucose, increase in lactate, increase in lactate/glucose ratio and increase in glycerol. Conclusion: 

In LPS-induced brain oedema i.v. infusion of low-dose PGI2 caused a further increase in ICP and a perturbation of energy metabolism, indicating cerebral ischemia and degradation of cellular membranes.

Keywords: Brain oedema; glucose; glycerol; intracranial pressure; lactate; lipopolysaccharide; microdialysis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1399-6576.2004.00522.x

Affiliations: 1: Department of Anaesthesiology, Malmö University Hospital, Malmö, 2: Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, 3: Department of Clinical Neuroscience, Lund University Hospital, Lund, Sweden

Publication date: November 1, 2004

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