Skip to main content

Women report more pain on injection of a precurarization dose of rocuronium: A randomized, prospective, placebo-controlled trial

Buy Article:

$43.00 plus tax (Refund Policy)

Background: 

The purpose of this study was to investigate whether gender influences the perception of pain on injection of rocuronium. Methods: 

In this prospective, placebo-controlled trial 120 patients were randomized into four groups to receive rocuronium 0.03 mg kg−1 (40 female and 40 male patients) or saline (20 female and 20 male patients). The incidence and severity of the injection pain after administration of the study drug was compared between female and male patients using a numerical rating scale (0–10). Signs of local irritation, i.e. erythema and thrombophlebitis, were assessed up to 48 h after surgery. Results: 

In 26 (32.5%) of the 80 patients receiving rocuronium, pain on injection was observed. This occurred significantly more frequently in the female compared with male patients: 18 (45%) vs. eight (20%), respectively (P = 0.032). The severity was more pronounced in the women than in the men (P = 0.020). The incidence of the rocuronium-associated pain was significantly increased compared with the Saline groups (P < 0.001). After surgery no patient complained of any residual pain and no local signs were observed in any patient during the study period. Conclusions: 

Women experienced more pain on injection of rocuronium than men, moreover this is an additional evidence for gender-related differences in pain perception. When rocuronium is used as a precurarization agent, an analgesic pretreatment (e.g. opioids) should be considered, especially for female patients.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Gender; injection; neuromuscular-blocking drugs; pain; pain perception; rocuronium; sex

Document Type: Research Article

Affiliations: Department of Anaesthesia and Intensive Care Medicine, University of the Saarland, Homburg/Saar, Germany

Publication date: 2004-11-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more