Skip to main content

The effects of etomidate, thiopental, and propofol in induction on hypoperfusion–reperfusion phenomenon during laparoscopic cholecystectomy

Buy Article:

$43.00 plus tax (Refund Policy)


A hypoperfusion–reperfusion human model is observed during and soon after laparoscopic surgery. The aim of the study was to research the preventive effects of etomidate, thiopental, and propofol in induction on hypoperfusion– reperfusion phenomenon during laparoscopic cholecystectomy. Methods: 

Thirty-six consecutive ASA I–II patients were randomized into three groups of 12 patients each. Anaesthesia was induced with etomidate in group 1, thiopental in group 2, and propofol in group 3. Venous blood samples were obtained at different time points for measurement of plasma malondialdehyde (MDA) levels. Arterial blood and gastric juice samples were obtained for the calculation of gastric intramucosal pH (pHi). Also changes in aminotransferases, alkaline phosphatase and total bilirubin levels were assessed. Results: 

There was a significant decrease in pHi at 1 min before desufflation (BD) and 20 min after desufflation (AD) compared with before insufflation (BI) in all groups. Plasma level of MDA was significantly increased in group 1 at 1 min BD and 20 min AD compared with before induction of anaesthesia (baseline). Malondialdehyde levels were decreased significantly in group 3 and increased non-significantly in group 2 at the same time points. Also AST and ALT levels were significantly increased in both groups 1 and 2 at 24 h postoperatively. Conclusion: 

Propofol with antioxidant activity may offer many advantages by scavenging reactive oxygen species and their metabolites in case of anticipated hypoperfusion–reperfusion phenomenon, such as would occur in laparoscopic surgery.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Anaesthetics; hypoperfusion–reperfusion; intravenous-etomidate; laparoscopic cholecystectomy; lipid peroxidation; propofol; thiopental

Document Type: Research Article

Affiliations: 1: The Ministry of Health Ankara Research and Training Hospital, Clinic of Anesthesiology and Reanimation, and 2: Hacettepe University School of Medicine, Department of Biochemistry, Ankara, Turkey

Publication date: 2004-07-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more