Disturbing post-operative symptoms are not reduced by prophylactic antiemetic treatment in patients at high risk of post-operative nausea and vomiting

Authors: Alkaissi, A.1; Gunnarsson, H.2; Johnsson, V.2; Evertsson, K.1; Ofenbartl, L.3; Kalman, S.1

Source: Acta Anaesthesiologica Scandinavica, Volume 48, Number 6, July 2004 , pp. 761-771(11)

Publisher: Wiley-Blackwell

Buy & download fulltext article:

OR

Price: $48.00 plus tax (Refund Policy)

Abstract:

Background: 

To give prophylactics or timely treatment for post-operative nausea and vomiting (PONV) is the question. We compared the intensity and number of disturbing post-operative symptoms (i.e. pain, PONV, headache, fatigue, etc.) after prophylactic antiemetic treatment in a group of patients with >30% risk for post-operative vomiting. Methods: 

Four hundred and ninety-five patients, from three hospitals, planned for gynaecological surgery were randomized double blind. They were given granisetron 3 mg, droperidol 1.25 mg or no prophylactic antiemetic. Post-operative symptoms were followed for 24 h using a questionnaire. Symptoms were analyzed both according to their intensity and in a dichotomous fashion. Results: 

The intensity of different symptoms differed depending on whether droperidol, granisetron or no antiemetic had been given (P = 0.005) but the overall incidence of moderate to very severe symptoms was similar in all groups. No group fared better in general. The total number of symptoms was higher in the groups given prophylactic treatment (P < 0.05). The relative risk reduction for PONV with granisetron or droperidol prophylaxis was 27%[95% confidence interval (CI) 8–43] and 22% (2–38), respectively. The NNT (number needed to treat) for granisetron (0–24 h) was 7 and for droperidol 8. The NNH (number needed to harm) (0–24 h) for headache and visual disturbances was 6 and 13 (NS) for granisteron and, 50 (NS) and 6 for droperidol. Conclusion: 

The intensity of symptoms or the total number of disturbing symptoms did not decrease after prophylactic antiemetic treatment in a group of patients, but the profile of disturbing symptoms changed. The relevance of post-operative symptoms in terms of patients' well-being needs to be addressed.

Keywords: antiemetic prophylaxis; droperidol; granisetron; headache; post-operative fatigue; post-operative nausea and vomiting

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.0001-5172.2004.00403.x

Affiliations: 1: University Hospital in Linköping, 2: Västervik Hospital and 3: Eksjö Hospital, Sweden

Publication date: July 1, 2004

Related content

Tools

Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page