Skip to main content

Ephedrine in the cat lung vasculature

Buy Article:

$51.00 plus tax (Refund Policy)



Ephedrine is one of the most commonly used non-catecholamine sympathomimetic agents. It is used in operating rooms and critical care settings worldwide. While it has many side effects, its ability to rapidly raise blood pressure makes it an ideal agent to maintain homeostasis as well as in emergency situations. While its effects are known to be mediated by an α-mediated mechanism, the exact α subtype is unknown. In addition, no studies using ephedrine have been performed in the pulmonary vascular bed of the cat. Methods: 

The effects of phentolamine, a non-selective α-receptor blocker, and prazosin, an α1-selective antagonist, were investigated on pulmonary arterial responses to ephedrine, phenylepherine, norepinephrine, and U-46619. Lobar arterial perfusion pressure was continuously monitored, electronically averaged, and recorded with constant flow in the isolated left lower lobe vascular bed of the cat. Results: 

Phentolamine and prazosin significantly reduced vasoconstrictor pulmonary perfusion pressure increases induced by ephedrine. Conclusion: 

Ephedrine has significant vasopressor activity in the pulmonary vascular bed of the cat meditated predominantly by α1 adrenergic receptor activation.

Keywords: ephedrine; lung; pulmonary hypertension; vasoconstriction

Document Type: Research Article


Affiliations: Department of Anesthesiology and Pharmacology, Texas Tech University School of Medicine, Lubbock, Texas, USA

Publication date: 2003-09-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more