A lung recruitment maneuver immediately before rescue surfactant therapy does not affect the lung mechanical response in immature lambs with respiratory distress syndrome

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Abstract:

Background: 

In animals with acquired surfactant-deficiency, a recruitment maneuver by increased tidal volumes enhances the effect of exogenous surfactant. In contrast, in the preterm lamb model, hyperinflation early after birth impairs the effect of surfactant prophylaxis. Here we examined whether a lung recruitment maneuver just before surfactant would affect the response to rescue treatment in immature lambs with established respiratory distress syndrome (RDS). Methods: 

Five pairs of preterm twin lambs with gestational age 127 days were delivered by cesarean section and supported by pressure-limited mechanical ventilation for 4 h. At 30 min of age, when all the lambs were in severe respiratory failure, they were treated with porcine surfactant, 200 mg kg−1. One lamb in each pair was subjected to a lung recruitment maneuver consisting of five sustained inflations of 20 ml kg−1 just before surfactant instillation. Results: 

At 10 min after surfactant treatment, all the lambs showed a large improvement in oxygenation and an increase in inspiratory capacity and static compliance. Except for a transiently better oxygenation after surfactant therapy in the recruitment group (P < 0.05), there was no significant between-group differences in gas exchange or lung mechanics at any time point during the study. There was no difference in post mortem intrapulmonary air volume or alveolar expansion in histologic lung sections between groups. Conclusion: 

This small study does not show any positive or negative effect of a lung recruitment maneuver on the response to rescue surfactant therapy in immature animals with RDS.

Keywords: Animals; lung recruitment; newborn; pulmonary surfactants; respiratory distress syndrome

Document Type: Research Article

DOI: http://dx.doi.org/10.1034/j.1399-6576.2003.00202.x

Affiliations: 1: Department of Anesthesiology, University Hospital MAS, Malmö, Sweden, 2: Department of Paediatrics, University Hospital, Lund, Sweden, 3: Section of Clinical Chemistry,Department of Surgical Sciences, Karolinska Hospital, Stockholm, Sweden, 4: Department of Anesthesiology, Gentofte University Hospital, Hellerup, Denmark, 5: Laboratory for Surfactant Research, Department of Surgical Sciences, Karolinska Hospital, Stockholm, Sweden, 6: Department of Pediatric Anesthesia, University Hospital, Lund, Sweden

Publication date: September 1, 2003

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