A randomised double-blind evaluation of adenosine as adjunct to sufentanil in spinal labour analgesia

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Abstract:

Background:

Intrathecal injection of sufentanil offers labour pain relief of short duration. This double-blind randomised study evaluates if the combination of adenosine to sufentanil could give relevant prolongation (40%) of the duration of sufentanil spinal analgesia. Methods:

Twenty-five healthy parturients requesting labour analgesia were included. Patients received 10 µg of sufentanil + 500 µg of adenosine or 10 µg of sufentanil intrathecally. Pain intensity and duration of pain relief were assessed. Results:

Pain relief was equal between groups. Duration of analgesia was not increased by adenosine + sufentanil, 99 ± 54 min, vs. sufentanil, 89 ± 56 min. Conclusion:

Adding 500 µg of adenosine to 10 µg of sufentanil could not provide any prolongation of labour pain relief.

Keywords: Adenosine; intrathecal; labour analgesia; opioids; spinal analgesia

Document Type: Research Article

DOI: http://dx.doi.org/10.1034/j.1399-6576.2003.00110.x

Affiliations: 1: Department of Anaesthesia and Intensive Care, Danderyd Hospital, Danderyd and 2: Department of Anaesthesia and Intensive Care, Huddinge University Hospital, Stockholm, Sweden

Publication date: May 1, 2003

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