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Propofol pharmacokinetics in a dwarfism patient

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Pharmacokinetic information is important to control anesthetic depth. However, there are few available pharmacokinetic data of propofol in dwarfism patients. We anesthetized a dwarfism patient who underwent spinal decompression, and investigated the pharmacokinetics of propofol. The patient was a 40-year-old man suffering from muscle weakness and numbness in the arms. The operation consisted of two stages; anterior approach in the supine position and posterior approach in the prone position. We also obtained arterial blood for pharmacokinetic analysis. Distribution volume at steady-state and clearance in the supine position was 180 and 0.92 l min− 1, respectively, and in the prone position 127 and 0.74 l min− 1, respectively, in spite of a continuous infusion of dopamine. The data in the supine position were well predicted by Gepts' parameters (used in Diprifusor® Zeneca Ltd, Cheshire, UK), which means the target-controlled infusion (TCI) technique can be available in the supine position, while attention is necessary to avoid overdosing when a patient is placed in the prone position.

Keywords: anesthetics; dwarfism; intravenous; pharmacokinetics; prone position; propofol

Document Type: Research Article


Affiliations: Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Faculty of Medicine, Kanazawa University, Kanazawa, Japan

Publication date: 2003-04-01

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