Skip to main content

Inhibitory effects of desflurane and sevoflurane on contractions of isolated gravid rat myometrium under oxytocin stimulation

Buy Article:

$51.00 plus tax (Refund Policy)



We studied the inhibitory effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated gravid rat myometrium. Methods:

Twenty strips were obtained from rats and these were randomly assigned into two groups. The effects of desflurane and sevoflurane were evaluated by treating strips with oxytocin alone 2×10−9 M or with oxytocin after desflurane and sevoflurane at 0.5, 1, and 2 MAC. Results:

Oxytocin significantly increased the amplitude and duration of contractions (P< 0.05), but it did not increase the frequency. The duration (84%, 79%), amplitude (90%, 84%) and frequency (88%, 75%) were inhibited at 2 MAC of desflurane and sevoflurane, respectively. Conclusion:

These results suggest that the in vitro application of desflurane and sevoflurane similarly inhibit oxytocin-induced myometrial contractions of gravid rat in a dose-dependent manner.

Keywords: Desflurane; gravid; isolated; minimum alveolar concentration; myometrium; oxytocin; rat; sevoflurane

Document Type: Research Article


Affiliations: 1: Anesthesiology and 2: Pharmacology, Erciyes University School of Medicine, Kayseri, Turkey

Publication date: April 1, 2003


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more