Comparison between intra-articular bupivacaine with epinephrine and epinephrine alone on short-term and long-term pain after knee arthroscopic surgery under general anesthesia in day-surgery patients

Authors: Toivonen J.¹; Pitko V.-M.²; Rosenberg P.H.³

Source: Acta Anaesthesiologica Scandinavica, Volume 46, Number 4, April 2002 , pp. 435-440(6)

Publisher: Wiley-Blackwell

Abstract:

Postarthroscopy analgesia has been provided with intra-articular bupivacaine, but reported results are conflicting regarding efficacy and the duration of analgesia. The immediate and long-term effects of intra-articular bupivacaine with epinephrine after arthroscopic knee surgery were therefore studied in a day surgery setting.

Methods:

120 ASA I–II patients scheduled for arthroscopic knee surgery were given general anesthesia with spontaneous breathing via a laryngeal mask. In a randomized and blinded fashion half of them received, at the end of surgery, intra-articularly 20 mL 0.5% bupivacaine with epinephrine (B + E-group) and the other half 20 mL saline with epinephrine (S + E-group). All patients received ketoprofen 100 mg i.v. during surgery and another 100 mg 2–3 h postoperatively. The patients were observed for about 4.5 h in the day surgery unit before discharge.

Results:

The results showed that in comparison with the S + E-group, significantly fewer patients in the B + E-group needed analgesics (P < 0.0001) and the amount required was also significantly less postoperatively, before discharge (about 4.5 h postoperatively) (P < 0.0001). The latency to the need for the first postoperative analgesic was shorter in the S + E-group patients (P < 0.0001). At home, during seven days after discharge, the need for analgesic (oral ketoprofen 100 mg) was greater in the B + E-group (P < 0.05), especially only during the second postoperative day, but the visual analoque pain scale (VAPS) scores were low with no differences between the groups. No complication occurred.

Conclusion:

It is concluded that a good postoperative pain control of intra-articular bupivacaine with epinephrine was found only in the immediate postoperative period (i.e. before discharge) in a day-surgery arthroscopic knee surgery patients.

Keywords: anesthesia; day surgery; anesthetic technigues; anesthetics; local; intra-articular; bupivacaine; pain; postoperative; surgery; knee arthroscopy

Language: English

Document Type: Original article

DOI: http://dx.doi.org/10.1034/j.1399-6576.2002.460418.x

Affiliations: 1: Departments of Anesthesia and 2: Surgery, South Carelian Central Hospital, Lappeenranta, and 3: Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland

Publication date: 2002-04-01

• In this: publication
• By this: publisher
• In this Subject: Surgery
• By this author: Toivonen J. ;  Pitko V.-M. ;  Rosenberg P.H.

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