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Pharmacokinetics of a 24-hour intravenous ketoprofen infusion in children

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Abstract:

Background:

No pharmacokinetic data are available with respect to the plasma concentration of ketoprofen during intravenous infusion in children. Methods:

We present here the pharmacokinetics of ketoprofen after a 10-min intravenous infusion of 1 mg/kg followed by a 24-h infusion of 4 mg/kg in 18 children aged 7 months to 16 years. Venous blood samples were collected at 5 min, 1, 2, 4, 24 h following the loading dose, and then 1, 2 and 4 h after the end of the infusion. A validated HPLC method was used to measure plasma levels of ketoprofen. Results:

The steady state plasma concentration of ketoprofen was 2.0 µg/mL (range 1.3–2.7 µg/mL). The clearance of ketoprofen was 0.09 L·h−1·kg−1 (range 0.06–0.13 L·h−1·kg−1). The distribution volume was 0.16 L/kg (range 0.12–0.21 L/kg). The terminal half-life was 1.3 h (range 0.8–1.7 h). Conclusion:

The pharmacokinetics of ketopofen in children is similar to that reported in adults. Our results indicate that ketoprofen is a feasible drug for continuous intravenous infusion in acute pain treatment in children.

Keywords: analgesics; anesthesia combined spinal-epidural; child; controlled clinical trial; dosage forms; injection; ketoprofen; non-opioid; opioid; pharmacokinetics; sufentanil

Document Type: Research Article

DOI: http://dx.doi.org/10.1034/j.1399-6576.2002.460213.x

Affiliations: 1: Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, and 2: Aventis Pharma, Helsinki, Finland

Publication date: February 1, 2002

mksg/aas/2002/00000046/00000002/art00013
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