Skip to main content

Pharmacokinetics of a 24-hour intravenous ketoprofen infusion in children

Buy Article:

$51.00 plus tax (Refund Policy)



No pharmacokinetic data are available with respect to the plasma concentration of ketoprofen during intravenous infusion in children. Methods:

We present here the pharmacokinetics of ketoprofen after a 10-min intravenous infusion of 1 mg/kg followed by a 24-h infusion of 4 mg/kg in 18 children aged 7 months to 16 years. Venous blood samples were collected at 5 min, 1, 2, 4, 24 h following the loading dose, and then 1, 2 and 4 h after the end of the infusion. A validated HPLC method was used to measure plasma levels of ketoprofen. Results:

The steady state plasma concentration of ketoprofen was 2.0 µg/mL (range 1.3–2.7 µg/mL). The clearance of ketoprofen was 0.09 L·h−1·kg−1 (range 0.06–0.13 L·h−1·kg−1). The distribution volume was 0.16 L/kg (range 0.12–0.21 L/kg). The terminal half-life was 1.3 h (range 0.8–1.7 h). Conclusion:

The pharmacokinetics of ketopofen in children is similar to that reported in adults. Our results indicate that ketoprofen is a feasible drug for continuous intravenous infusion in acute pain treatment in children.

Keywords: analgesics; anesthesia combined spinal-epidural; child; controlled clinical trial; dosage forms; injection; ketoprofen; non-opioid; opioid; pharmacokinetics; sufentanil

Document Type: Research Article


Affiliations: 1: Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, and 2: Aventis Pharma, Helsinki, Finland

Publication date: February 1, 2002


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more