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Endogenous morphine is produced in response to cardiopulmonary bypass in neonatal pigs

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Cardiopulmonary bypass (CPB) is associated with a systemic inflammatory response. Endogenous morphine production has previously been demonstrated in humans after cardiac surgery with CPB. It has been hypothesized that morphine plays a role as an anti-inflammatory mediator in the systemic inflammatory response. The aim of this study was to investigate if the CPB procedure in itself elicits an endogenous morphine production in neonatal pigs. Methods:

Endogenous morphine production was measured in arterial blood in piglets exposed to sternotomy alone (sham group, n=10) or sternotomy and CPB (n=10). Blood samples were obtained immediately after the induction of anaesthesia, at the end of CPB and 4 h later. Morphine in arterial blood was detected by radioimmunoassay and confirmed by gas chromatography mass spectrometry. Results:

Animals undergoing CPB showed detectable endogenous morphine concentrations immediately after CPB, with increased concentrations postoperatively. There was no measurable morphine production in the sham operated pigs. Conclusion:

The CPB procedures elicits an endogenous morphine production in neonatal pigs. This morphine response is analogous to the previously demonstrated response in patients subjected to cardiac surgery and CPB.

Keywords: Cardiopulmonary bypass; anesthetics; endogenous morphine; fentanyl; intravenous; piglets

Document Type: Research Article


Affiliations: 1: Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark 2: Neuroscience Research Institute, State University of New York at Old Westbury, New York, and 3: Cardiac Research Program, University Medical Center, State University of New York at Stony Brook, New York, USA

Publication date: November 1, 2000

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