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Use of an EEG-bispectral closed-loop delivery system for administering propofol

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Closed-loop control of propofol delivery was instituted in three patients who received a propofol infusion as part of: (Case 1) general “balanced” anesthesia, (Case 2) total intravenous anesthesia, and (Case 3) monitored anesthesia care. The bispectral index was the input variable used in a proportioned, integral and differential controller to determine the infusion rate of propofol required to maintain a stable level of hypnosis (Cases 1 and 2) or sedation (Case 3). This feedback control system provided intraoperative hemodynamic stability and a prompt recovery from the sedative-hypnotic effects of propofol.

Keywords: Anesthetics; computer-controlled infusion; intravenous; propofol

Document Type: Research Article

DOI: http://dx.doi.org/10.1034/j.1399-6576.2000.440819.x

Affiliations: 1: Department of Anesthesiology, University of Hirosaki School of Medicine, Japan 2: Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Texas, USA

Publication date: September 1, 2000

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