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Randomised, placebo-controlled study of the postoperative analgesic effects of ketoprofen after spinal fusion surgery

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The additive effect of non-steroidal anti-inflammatory drugs administered with propacetamol after major orthopaedic surgery has not been studied. Thus, we performed a prospective, placebo-controlled study to assess the analgesic effects of ketoprofen in patients undergoing spinal fusion surgery and receiving propacetamol. Methods:

Fifty patients undergoing spinal fusion surgery received either 100 mg of ketoprofen every 8 h or a placebo, postoperatively. All patients received propacetamol and morphine (intravenous titration followed by patient-controlled analgesia (PCA) over 24 h). Pain was assessed using a visual analogue pain scale (VASpi). Data are mean±SD. Results:

During morphine titration, ketoprofen did not significantly reduce the dose of morphine (8±6 vs 11±4 mg, NS) whereas it significantly decreased VASpi (P<0.001). During PCA, ketoprofen significantly reduced morphine consumption (25±17 vs 38±20 mg, P=0.04) and VASpi (P=0.002). The total postoperative morphine consumption was significantly (33%) reduced with ketoprofen. Conclusion:

Ketoprofen reduced morphine requirements and improved postoperative analgesia in patients undergoing major spinal surgery and receiving propacetamol.

Keywords: Pain, postoperative; analgesia, patient-controlled; analgesics, opioids, ketoprofen; non-steroidal anti-inflammatory agents, ketoprofen; randomised clinical trial

Document Type: Research Article


Publication date: September 1, 2000

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