Authors: Matusiak, Łukasz; Bieniek, Andrzej; Szepietowski, Jacek C.

Source: Acta Dermato-Venereologica, Volume 89, Number 6, October 2009 , pp. 601-603(3)

Publisher: Medical Journals Limited

Abstract:

Hidradenitis suppurativa (HS) is a recurrent, debilitating suppurative skin disease. Nowadays the major challenge is the choice of optimal treatment. Many conservative therapies seem to have only a supportive character and do not prevent progression of the disease. Early surgical intervention with complete excision of the involved areas is still considered to be the most efficient therapy, but anti-tumour necrosis factor (TNF)-α agents may offer a possible non-surgical treatment. The aim of this study was to determine the serum concentration of TNF-α and its probable alterations during the disease process in patients with HS. Analysis of TNF-α serum concentration in 54 individuals with HS revealed significantly higher levels than in the sera of healthy controls (p=0.006). To the best of our knowledge, this is the first report of increased TNF-α serum concentration in patients with HS.

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Keywords: HIDRADENITIS SUPPURATIVA; ACNE INVERSA; TNF-ALPHA; INFLIXIMAB; ETANERCEPT; ADALIMUMAB

Document Type: Research article

DOI: http://dx.doi.org/10.2340/00015555-0749

Publication date: 2009-10-01

More about this publication?

• Acta Dermato-Venereologica is a bi-monthly international peer-reviewed journal for clinical and experimental research in the field of dermatology and venereology.
  
  It was founded in 1920 by Johan Almqvist and edited during 1936-1969 by Sven Hellerström. Since 1970, the journal has been published for the Society for the Publication of Acta Dermato-Venereologica on a non-profit basis.
  
  Acta Dermato-Venereologica publishes high-quality manuscripts in English dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. AActa Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs to enhance understanding.
  
  Acta Dermato-Venereologica covers inter alia:

  • ~ Atopic dermatitis and contact allergy
  • ~ Facial dermatoses and adnexal disorders
  • ~ New treatments
  • ~ Psoriasis and genodermatoses
  • ~ Psychodermatology
  • ~ Sexually transmitted diseases
  • ~ Skin biology and inflammation
  • ~ Skin cancer and pigmentation
  • ~ Skin immunology and lymphoma
  • ~ Urticaria and itch

  
  Extensive papers, proceedings from congresses and symposia are printed as supplements to the journal. Announcements concerning pertinent dermatological meetings and books received are also published.
  Readership: Doctors and scientists interested in dermatology, skin biology and venereology.
  
  Acta Dermato-Venereologica has an impact factor of 3.007.
  
  Issues between 1998 up to 2005 can be found at http://www.medicaljournals.se/acta/content

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