Authors: Haslund, Pia; Lee, Robert A.; Jemec, Gregor B.E.

Source: Acta Dermato-Venereologica, Volume 89, Number 6, October 2009 , pp. 595-600(6)

Publisher: Medical Journals Limited

Abstract:

Hidradenitis suppurativa (HS) is a common inflammatory skin disease. Medical treatment is often disappointing and in severe disease surgery remains the therapy of choice. Extensive surgery may be effective but also mutilating. Patients experience a significant reduction in quality of life and the need for new treatment modalities are urgent. In recent years patients with HS have been treated off-label with tumour necrosis factor-α (TNF-α) inhibitors with a varying degrees of effect. We performed a systematic review of papers retrieved from two databases (PubMed and Web of Science) using the following keywords: hidradenitis suppurativa, acne inversa, infliximab, etanercept, and adalimumab. A total of 34 publications were retrieved, describing treatment of 105 patients. Most cases report treatment with infliximab (52/105). A positive treatment outcome was reported in 90/105 cases, with only 7/105 non-responders and 8/105 patients experiencing side-effects. The side-effects were comparable to those seen in other TNF-α inhibitor studies. In the majority of cases the treatment was effective when given as a suppressive therapy, but 15/105 cases were described with long-term remission (≥3 months) after the end of therapy. In most publications follow-up was, however, insufficient to allow a systematic exploration of this. TNF-α inhibitors seem to be effective in the treatment of HS. However, several questions remain to be answered through specific studies. This review has also identified a need for more standardized reporting of the outcomes as well as randomized controlled trials in this disease.

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Keywords: HIDRADENITIS SUPPURATIVA; TUMOUR NECROSIS FACTOR-ALPHA INHIBITORS; INFLIXIMAB; ETANERCEPT: ADALIMUMAB

Document Type: Review article

DOI: http://dx.doi.org/10.2340/00015555-0747

Publication date: 2009-10-01

More about this publication?

• Acta Dermato-Venereologica is a bi-monthly international peer-reviewed journal for clinical and experimental research in the field of dermatology and venereology.
  
  It was founded in 1920 by Johan Almqvist and edited during 1936-1969 by Sven Hellerström. Since 1970, the journal has been published for the Society for the Publication of Acta Dermato-Venereologica on a non-profit basis.
  
  Acta Dermato-Venereologica publishes high-quality manuscripts in English dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. AActa Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs to enhance understanding.
  
  Acta Dermato-Venereologica covers inter alia:

  • ~ Atopic dermatitis and contact allergy
  • ~ Facial dermatoses and adnexal disorders
  • ~ New treatments
  • ~ Psoriasis and genodermatoses
  • ~ Psychodermatology
  • ~ Sexually transmitted diseases
  • ~ Skin biology and inflammation
  • ~ Skin cancer and pigmentation
  • ~ Skin immunology and lymphoma
  • ~ Urticaria and itch

  
  Extensive papers, proceedings from congresses and symposia are printed as supplements to the journal. Announcements concerning pertinent dermatological meetings and books received are also published.
  Readership: Doctors and scientists interested in dermatology, skin biology and venereology.
  
  Acta Dermato-Venereologica has an impact factor of 3.007.
  
  Issues between 1998 up to 2005 can be found at http://www.medicaljournals.se/acta/content

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