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Anticancer drugs loading into and in vitro release from faujasite

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Abstract:

This investigation was carried out to determine whether the adsorptive and ion-exchange properties of faujasite (FAU) could be used to delivery locally the anticancer drugs gemcitanine hydrochloride (dFdU.HCl) and oxaliplatin (DACH-Pt). A soaking procedure was used for the determination of the maximum adsorption capacity of FAU and the mechanism described here was achieved. 274 mg dFdU.HCl/g FAU were adsorbed in 16 h, while 48 h were needed for the adsorption of 79.7 mg DACH-Pt/g FAU. Drug release studies were carried out by soaking the samples of loaded FAU in simulation body fluids (SBF). After only one hour 76% of dFdU.HCl was released while the release of DACH-Pt from the FAU was more normal since 38% of DACH-Pt was released in the first 24 h.

Keywords: ADSORPTION AND RELEASE KINETICS; ANTICANCER DRUGS; BIOMATERIAL; DRUG CARRIER; FAUJASITE; MOLECULAR ELECTROSTATIC POTENTIAL; ZEOLITE

Document Type: Research Article

DOI: http://dx.doi.org/10.1180/claymin.2011.046.4.613

Publication date: December 1, 2011

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minsoc/cm/2011/00000046/00000004/art00007
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