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An Exploration of Participants' Treatment Preferences in a Partial RCT Une exploration des préférences des patients en matière de traitements dans le cadre d'une étude sur échantillon partiellement aléatoire et contrôlé

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Abstract:

The partial RCT is a modified design meant to account for participants' treatment preferences. Little is known about the factors that influence such preferences. This study investigated the extent to which participants are willing to be randomized and the factors that affect their treatment preferences. The quantitative and qualitative data collected as part of a partial RCT evaluating 2 behavioural interventions for insomnia were analyzed. Of the participants, 75% were unwilling to be randomly allocated to a treatment group. This figure increased to 90% after information on the 2 interventions was provided. Participants' knowledge of the treatment, its suitability, and their perceived ability to adhere to it influenced their treatment preference. A few participants who had no strong preference and who required treatment were willing to be randomized. The findings raise questions about the impact of treatment preference and allocation procedures on the validity of study conclusions.

French
L'étude sur échantillon partiellement aléatoire et contrôlé (ÉÉPAC) est une conception modifiée dont le but est de tenir compte des préférences des participants en matière de traitement. Les connaissances concernant les facteurs qui influencent ces préférences sont très limitées. Cette étude évalue le degré de consentement des participants à collaborer à un processus aléatoire ainsi que les facteurs qui influent sur leurs préférences en matière de traitement. Les données quantitatives et qualitatives cueillies dans le cadre d'une ÉÉPAC de deux interventions comportementales dans des cas d'insomnie ont été analysées. Parmi les participants, 75 % ont refusé d'être aléatoirement assignés à un groupe thérapeutique. Ce chiffre a grimpé à 90 % après l'introduction de renseignements concernant les deux interventions. L'information que détenaient les participants concernant le traitement, la pertinence de celui-ci et leur capacité d'y adhérer selon leur perception ont influencé leur préférence en matière de traitement. Quelques participants qui n'avaient pas de préférence marquée et qui nécessitaient un traitement étaient disposés à être assignés de façon aléatoire. Les résultats soulèvent des questions concernant l'impact de la préférence en matière de traitement et de la procédure d'assignation sur la validité des conclusions de l'étude.

Keywords: EEPAC; PARTIAL RCT; PREFERENCE EN MATIERE DE TRAITEMENT; RANDOM ASSIGNMENT; TREATMENT PREFERENCE

Document Type: Research Article

Publication date: September 1, 2004

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