Phosphoramidite-Controlled Asymmetric Hydrogenation with Rhodium Catalysts
Authors: Ager, David J.; de Vries, André H.M.; de Vries, Johannes G.
Source: Platinum Metals Review, Volume 50, Number 2, April 2006 , pp. 54-63(10)
Publisher: Johnson Matthey
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Abstract:
Phosphoramidites, and in particular those derived from BINOL, the MonoPhos family of ligands, have proven extremely useful for the asymmetric hydrogenation of carbon–carbon unsaturation using a rhodium catalyst. Many classes of alkenes can be reduced by these catalyst systems. The use of high-throughput experimentation can be applied to the synthesis of MonoPhos ligands and their subsequent screening, in order to find an appropriate candidate for a specific transformation. Suitable mixtures of ligands can also be found by these high-throughput methods.Document Type: Research article
DOI: 10.1595/147106706X111582
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