Ruthenium Polyaminocarboxylate Complexes

Authors: Chatterjee, Debabrata; Mitra, Anannya; De, G.S.

Source: Platinum Metals Review, Volume 50, Number 1, January 2006 , pp. 2-12(11)

Publisher: Johnson Matthey

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Abstract:

Ruthenium (Ru) complexes containing polyaminocarboxylate (pac) ligands (Ru-pac) have features which indicate they may be suitable for biological applications. For instance, Ru-pac complexes can bind to biomolecules through a rapid and facile aquo-substitution reaction, and Ru-pac has a range of accessible oxidation states. Ru-pac also has some notable catalytic properties that mimic enzymatic hydrocarbon oxidation by cytochrome P-450 in homogeneous conditions. This is of immense significance towards developing Ru-pac based agents for oxidative cleavage of DNA and artificial nuclease in DNA foot-printing experiments. This review aims to highlight the scope of Ru-pac complexes as metallopharmaceuticals, and outlines their potential for certain biological applications.

Document Type: Research article

DOI: 10.1595/147106705X82874

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