Ruthenium-Catalysed Asymmetric Reduction of Ketones
Authors: Zanotti-Gerosa, Antonio; Hems, William; Groarke, Michelle; Hancock, Fred
Source: Platinum Metals Review, Volume 49, Number 4, October 2005 , pp. 158-165(8)
Publisher: Johnson Matthey
Key:
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Abstract:
The asymmetric reduction of carbonyl, C=O, groups for the production of enantiomerically pure secondary alcohols is a reaction of fundamental importance in modern synthetic chemistry. This reaction can be performed in a number of ways. Asymmetric chemocatalysis (1) and the often complementary biocatalysis offer solutions to the stereoselective reduction of C=O groups. These two techniques have found wide industrial application (2). In the mid 1990s, two new ruthenium systems based on dihydrogen or transfer hydrogenation for asymmetric reduction of prochiral ketones were developed by Professors Noyori and Ikariya. These systems enable catalytic asymmetric reduction to provide a route for the generation of enantiomerically pure secondary alcohols in a highly efficient, simple and economic way (3). This paper describes some robust and cost-effective chemocatalytic technology for asymmetric ketone reduction, using ruthenium catalysts with diphosphine ligands.Document Type: Research article
DOI: 10.1595/147106705X75421
Key:
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Click here for Page Help