Lack of association between the 308GA polymorphism of the tumor necrosis factor alpha gene and temporomandibular dysfunction

Authors: Etőz, Osman; Erdal, M. Emin; Herken, Hasan; Bayazit, Yildirim; Mutlu, Murat Necip

Source: The Pain Clinic, Volume 18, Number 2, 2006 , pp. 175-180(6)

Buy & download fulltext article:

Price: $48.00 plus tax (Refund Policy)

Abstract:

Objective: To assess whether a relationship exists between G308A polymorphism of TNF-α gene and the temporomandibular dysfunction (TMD).

Methods: 98 patients with temporomandibular dysfunction, and 132 healthy volunteer controls were included in the study. Molecular analysis of the G308A polymorphism of TNF-α gene was performed using PCR technique.

Results: The ages and genders of the patients and controls were similar (Fisher exact test p = 0.5). There was no relationship between TNF 308GA polymorphism and TMD (χ ² = 4.24, p = 0.12). The allele frequencies of the patients and controls were similar (χ ² = 3.25, p = 0.076).

Keywords: TEMPOROMANDIBULAR DYSFUNCTION; TNF-ALPHA AND TNF-ALPHA-308GA POLYMORPHISM

Document Type: Research Article

DOI: http://dx.doi.org/10.1163/156856906776760443

Publication date: 2006-04-01

More about this publication?