Systemic effects of epidural betamethasone injection

Authors: Tuncer, Sema; Barişkaner, Hülagü; Yosunkaya, Alper; Reisli, Ruhiye; Ökesli, Selmin

Source: The Pain Clinic, Volume 16, Number 3, 2004 , pp. 311-315(5)

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Abstract:

A single epidural injection of a steroid may produce a suppression of the adrenocortical secretion. We aimed to evaluate systemic effects of a single epidural injection of betamethasone in this study. The study included 33 patients with low back pain. None of the patients had received local or systemic steroid therapy within 2 months before the injection. The epidural injection consisted of 10 mg of betamethasone diluted in 8 ml 0.25% bupivacaine. Injections were performed between 8:00 and 9:00 a. m. Before the injection in the same day (D0) cortisol, ACTH, fasting levels of glucose, triglycerides, cholesterol, sodium, and potassium were checked in the blood. The same assays were done again by the same laboratory at 15, 30, 45 min, and 7 (D7) and 21 (D21) days after the steroid injections. In all patients, cortisol and ACTH were normal at D0. ACTH and cortisol significantly decreased 45 min and at D7 after steroid injection, but returned to normal on D21. There were no significant changes in mean fasting glucose, sodium, potassium, triglycerides or cholesterol levels during the study. Blood pressure values were normal in all patients. As a result, it is concluded that a single epidural injection of betamethasone is associated with transient adrenal suppression.

Keywords: SYSTEMIC EFFECTS; EPIDURAL INJECTION; BETAMETHASONE

Document Type: Research Article

DOI: http://dx.doi.org/10.1163/1568569041798461

Publication date: 2004-08-01

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