IngentaConnect Levels of soluble intercellular adhesion molecule-1 in serum of p...

Authors: Naci Ezirmik; Mehmet Akyüz; Konca Altinkaynak; Kenan Gümüstekin; Adnan Yilmaz

Source: The Pain Clinic, Volume 16, Number 3, 2004 , pp. 306-309(4)

Abstract:

Ankylosing spondylitis (AS) is a chronic, progressive, inflammatory disorder mainly affecting axial skeleton and peripheral joints In this study, soluble intercellular adhesion molecule-1 (sICAM-1), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) in serum of patients with AS were investigated and compared with those of age- and sex-matched healthy controls. Twenty-one patients with AS not currently under disease-modifying antirheumatic drug (DMARD) treatment (e.g.sulfasalazine or methotrexate) and 20 age- and sex-matched healthy controls were included in the study. Serum sICAM-1, CRP, ESR levels were evaluated using appropriate methods. When compared with the levels in the control subjects, serum CRP and ESR in the patients with AS were significantly elevated. Although serum sICAM-1 levels were increased in AS patients compared with controls, the difference did not reach significance level. Significant positive correlations were observed between sICAM-1 and ESR (r= 0.60, p < 0.01), and between sICAM-1 and CRP (r= 0.48, p < 0.05).

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Levels of soluble intercellular adhesion molecule-1 in serum of patients with ankylosing spondylitis