The flavonoid morin restores blood pressure and lipid metabolism in DOCA-salt hypertensive rats
Authors: Prahalathan, Pichavaram; Saravanakumar, Murugesan; Raja, Boobalan
Source: Redox Report, Volume 17, Number 4, July 2012 , pp. 167-175(9)
Publisher: Maney Publishing
This study was undertaken to investigate the antihypertensive and antihyperlipedimic potential of morin against deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Hypertension was induced in uninephrectomized rats (UNX) by weekly twice subcutaneous injection of DOCA (25 mg/kg) and 1% NaCl in the drinking water for six consecutive weeks. Morin (50 mg/kg) was administered to DOCA-salt rats orally using an intragastric tube daily for a period of 6 weeks.
The DOCA-salt hypertensive rats showed significant elevation in mean arterial pressure (MAP), heart rate (HR) and reduction in body weight. A significant increase in the concentrations of plasma and tissue (liver, kidney, heart, and aorta) lipids such as total cholesterol, triglycerides, free fatty acids, phospholipids, plasma low-density and very low-density lipoproteins cholesterol, and a decrease in the concentration of high-density lipoprotein cholesterol were noticed in DOCA-salt hypertensive rats. Also, the levels of urinary protein and the activity of 3-hydroxy 3-methylglutaryl coenzyme A reductase in the plasma and tissues were increased, and lecithin cholesterol acyl transferase activity in the plasma was decreased in DOCA-salt rats. Morin supplementation (50 mg/kg) throughout the experimental period restored all the above parameters significantly.
Morin has a potential role in attenuating severe hypertension and hyperlipedimia.
Document Type: Research Article
Affiliations: Annamalai University, Annamalainagar, Tamil Nadu, India
Publication date: 2012-07-01