Analysis of HNE metabolism in CNS models

Authors: Kubatova, Alena¹; Honzatko, Ales²; Brichac, Jiri²; Long, Eric²; Picklo, Matthew J.³

Source: Redox Report, Volume 12, Numbers 1-2, February 2007 , pp. 16-19(4)

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Abstract:

The formation and toxicity of trans-4-hydroxy-2-nonenal in the central nervous system is well documented. However, the metabolism of HNE in the central nervous system (CNS) is not clear. HNE metabolism in the CNS appears to be different from that in other tissues and organs and may be dependent on the cell type and subcellular environment. Our data show that HNE metabolism is affected by the stereocenter of HNE and that oxidation of HNE may be a primary route of metabolism. Further metabolic analysis of HNE disposition is needed to clarify which pathways are truly important in normal and pathological states in the CNS.

Keywords: TRANS-4-HYDROXY-2-NONENAL; STEREOCENTER; CENTRAL NERVOUS SYSTEM

Document Type: Regular Paper

DOI: http://dx.doi.org/10.1179/135100007X162149

Affiliations: 1: Department of Chemistry, University of North Dakota, Grand Forks, North Dakota, USA 2: Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota, USA 3: Department of Chemistry, University of North Dakota, Grand Forks, North Dakota, USA; Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota, USA

Publication date: 2007-02-01

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