Home >> Redox Report, Volume 11, Number 3

Dipyrone and aminopyrine are effective scavengers of reactive nitrogen species

Authors: Costa, David1; Vieira, Abel2; Fernandes, Eduarda1

Source: Redox Report, Volume 11, Number 3, June 2006 , pp. 136-142(7)

Publisher: Maney Publishing

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Abstract:

Reactive nitrogen species (RNS), namely nitric oxide (NO•) and peroxynitrite (ONOO?) are produced in the inflammatory sites and may contribute to the deleterious effects of inflammation. The aim of the present study was to evaluate the putative scavenging effect of a particular group of non-steroidal anti-inflammatory drugs (NSAIDs), the pyrazolone derivatives dipyrone, aminopyrine, isopropylantipyrine, and antipyrine against RNS, using in vitro non-cellular screening systems. The results obtained showed that dipyrone and aminopyrine were highly potent scavengers of NO• and ONOO? while antipyrine exerted little effect and isopropylantipyrine no effect whatsoever against these two RNS and that, in the presence of bicarbonate, the scavenging potencies of both dipyrone and aminopyrine were slightly decreased. It could thus be inferred that the observed scavenging effects may be of therapeutic benefit for patients under anti-inflammatory treatment with dipyrone and aminopyrine in the case of overproduction of RNS. On the other hand, the possible depletion of physiological NO• concentrations, namely at the gastrointestinal tract as well as the formation of reactive derivatives of aminopyrine and/or dipyrone, resulting from their reaction with RNS, may otherwise be harmful for these patients.

Keywords: NITRIC OXIDE; DIPYRONE; AMINOPYRINE; ISOPROPYLANTIPYRINE; REACTIVE NITROGEN SPECIES; PEROXYNITRITE; ANTIPYRINE

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/135100006X116637

Affiliations: 1: REQUIMTE, Departamento de Química-Física, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal 2: REQUIMTE, CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal

Publication date: 2006-06-01

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