Home >> Redox Report, Volume 11, Number 1

Systemic NF-κB activation in blood cells of breast cancer patients

Authors: Adžić, Miroslav1; Nićiforović, Ana1; Vučić, Vesna1; Nešković-Konstantinović, Zora2; Spasić, Snežana3; Jones, David4; Radojčić, Marija1; Spasić, Mihajlo5

Source: Redox Report, Volume 11, Number 1, February 2006 , pp. 39-44(6)

Publisher: Maney Publishing

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Abstract:

There is a well-established role for reactive oxygen and nitrogen species, chronic inflammation and immune response in the pathogenesis of breast cancer. Complex interactions between breast cancer cells and surrounding blood vessels are prerequisites for cancer growth and invasion. Reports in the literature concerning the systemic response to, and the effect of, common breast cancer therapy on NF-?B and antioxidative defence enzyme expression and activity under clinical conditions are scarce. We determined these parameters in whole blood cell lysate from 16 women with breast cancer before and after combined (cyclophosphamide, doxorubicin, 5-fluorouracil; CAF) therapy and compared the results with 16 healthy women. Significantly higher levels of NF-?B and Mn-SOD (both their protein level and their activity) were found in breast cancer patients before and after CAF therapy, in comparison with healthy women. In parallel measurements, no change in the level or activity of catalase (CAT) was detected. According to our findings, it appears that breast cancer creates conditions that increase the level of hydrogen peroxide in the circulating cells and that the applied CAF therapy fails to compensate, therefore creating systemic conditions that favour survival and invasion of breast cancer cells.

Keywords: MN-SOD; CAT; BREAST CANCER; NF-KAPPAB

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/135100006X101002

Affiliations: 1: VINČA Institute of Nuclear Sciences, 'Siniša Stanković', Belgrade, Serbia and Montenegro 2: Institute of Oncology and Radiology of Serbia, 'Siniša Stanković', Belgrade, Serbia and Montenegro 3: Center for Chemistry ICHTM, 'Siniša Stanković', Belgrade, Serbia and Montenegro 4: Department of Biochemistry, Faculty of Chemistry, Institute for Biological Research, 'Siniša Stanković', Belgrade, Serbia and Montenegro 5: Department of Biochemistry, Faculty of Chemistry, Institute for Biological Research, 'Siniša Stanković', Belgrade, Serbia and Montenegro; Department of Physiology, Institute for Biological Research, 'Siniša Stanković', Belgrade, Serbia and Montenegro

Publication date: 2006-02-01

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