Authors: Marques da Silva Paula, Marcos¹; Pich, Claus Tröger¹; Petronilho, Fabrícia²; Drei, Lilian Batista¹; Rudnicki, Martina³; Roberto de Oliveira, Marcos³; Moreira, José Cláudio Fonseca³; Henriques, João Antônio Pegas⁴; Franco, César Vittorio⁵; Dal Pizzol, Felipe⁶

Source: Redox Report, Volume 10, Number 3, June 2005 , pp. 139-143(5)

Publisher: Maney Publishing

Abstract:

Many biological properties have been attributed to ruthenium complexes including anti-tumor activity and the attenuation of reperfusion damage and infarct size. In this work, we characterize the antioxidant activity of trans-[RuCl₂(nic)₄] where nic is 3-pyridinecarboxylic acid and trans-[RuCl₂(i-nic)₄] where i-nic is 4-pyridinecarboxylic acid by (i) evaluation of total antioxidant potential (TRAP); (ii) prevention of DNA damage induced by hydrogen peroxide using the alkaline comet assay; and (iii) the prevention of lipid peroxidation and cell death induced by iron in liver slices. Our results suggest that nic has stronger antioxidant potential when compared to the i-nic. Higher doses (above 200 ?M) of these compounds gave genotoxic effects, but the antioxidant potential could be obtained with the use lower doses (0.1–10 ?M).

Keywords: GENOTOXIC; OXIDATIVE DAMAGE; RUTHENIUM; ANTIOXIDANT; COMET ASSAY

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/135100005X38897

Affiliations: 1: Laboratório de Síntese de Complexos Multifuncionais, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil 2: Laboratório de Fisiopatologia Experimental, UNESC, SC, Brazil 3: Centro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil 4: Centro de Biotecnologia, UFRGS, Porto Alegre, RS, Brazil; Curso de Farmácia, Universidade Luterana do Brasil, Canos, RS, Brazil 5: Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil 6: Centro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Laboratório de Fisiopatologia Experimental, UNESC, SC, Brazil

Publication date: 2005-06-01

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• By this author: Marques da Silva Paula, Marcos ;  Pich, Claus Tröger ;  Petronilho, Fabrícia ;  Drei, Lilian Batista ;  Rudnicki, Martina ;  Roberto de Oliveira, Marcos ;  Moreira, José Cláudio Fonseca ;  Henriques, João Antônio Pegas ;  Franco, César Vittorio ;  Dal Pizzol, Felipe

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