Authors: Singh, Sarika¹; Das, T.¹; Ravindran, A.¹; Chaturvedi, R.K.²; Shukla, Y.²; Agarwal, A.K.²; Dikshit, M.¹

Source: Redox Report, Volume 10, Number 2, April 2005 , pp. 103-109(7)

Publisher: Maney Publishing

Abstract:

The present study was undertaken to explore involvement of nitric oxide (NO) in the experimental models of Parkinson's disease. Neurodegeneration was induced by unilateral injections of 6-hydroxydopamine (6-OHDA) or lipopolysaccharide (LPS) in the right striatum. Lesions were functionally evaluated by amphetamine-induced asymmetrical behaviour and by decrease in the tyrosine hydroxylase (TH) immunostaining. An induction in the expression of iNOS and augmentation in nitrite content was observed in both the models. The extent of increase in iNOS expression was, however, different but the elevation in the nitrite content was comparable in both the models. The increase in iNOS expression inversely correlated with the tyrosine hydroxylase (TH) immunolabeling. Animals pretreated with a NOS inhibitor, N^G-nitro-L-arginine methyl ester (L-NAME), exhibited complete protection against amphetamine induced rotations in both the models. Thus, augmented NO availability subsequent to iNOS induction seems to play an important role in the initial phase of neurodegeneration.

Keywords: INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; PARKINSON'S DISEASE; TYROSINE HYDROXYLASE; 6-HYDROXYDOPAMINE; NITRIC OXIDE

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/135100005X38842

Affiliations: 1: Division of Pharmacology, Central Drug Research Institute, Lucknow, India 2: Industrial Toxicology Research Center, Lucknow, India

Publication date: 2005-04-01

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