Quinolinic acid induces NMDA receptor-mediated lipid peroxidation in rat brain microvessels

Authors: Št'astný, František¹; Lisý, Václav²; Mareš, Vladislav²; Lisá, Vera²; Balcar, Vladimir³; Santamaría, Abel⁴

Source: Redox Report, Volume 9, Number 4, August 2004 , pp. 229-233(5)

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Abstract:

Quinolinic acid increased the generation of lipid peroxidation products by isolated rat brain microvessels in vitro. The effect was inhibited both by a specific NMDA receptor antagonist D-2-amino-5-phosphonovaleric acid and by reduced glutathione (GSH). Furthermore, quinolinic acid displaced specific binding of [³H]-L-glutamate by cerebral microvessel membranes, particularly in the presence of NMDA receptor co-agonist (glycine) and modulator (spermidine). We conclude that quinolinic acid can cause potentially cytotoxic lipid peroxidation in brain microvessels via an NMDA receptor mediated mechanism.

Keywords: QUINOLINATE; LIPID PEROXIDATION; BRAIN CAPILLARIES; DEMENTIA; NEURODEGENERATION; BLOOD-BRAIN BARRIER

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/135100004225006001

Affiliations: 1: Prague Psychiatric Centre affiliated with Charles University 3rd Faculty of Medicine, Prague, and Institute of Physiology, Academy of Sciences, Prague, Czech Republic 2: Institute of Physiology, Academy of Sciences, Prague, Czech Republic 3: Institute for Biomedical Research and School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia 4: Department of Neurochemistry, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez, Mexico City, Mexico

Publication date: 2004-08-01

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