Home >> Redox Report, Volume 9, Number 3

Understanding the association between dietary antioxidants, redox status and disease: is the Total Antioxidant Capacity the right tool?

Authors: Serafini, Mauro1; Del Rio, Daniele2

Source: Redox Report, Volume 9, Number 3, June 2004 , pp. 145-152(8)

Publisher: Maney Publishing

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Abstract:

Total Antioxidant Capacity (TAC) considers the cumulative action of all the antioxidants present in plasma and body fluids, thus providing an integrated parameter rather than the simple sum of measurable antioxidants. The capacity of known and unknown antioxidants and their synergistic interaction is, therefore, assessed, thus giving an insight into the delicate balance in vivo between oxidants and antioxidants. There is new evidence indicating the importance of understanding the mechanisms of the homeostatic control of TAC in plasma and tissues and its modification during oxidative stress development. Recently, the epidemiological application of TAC has been proposed as a new tool for investigating the relationship between dietary antioxidants and cancer risk in population studies. This review outlines the pros and cons of the more common assays for measuring plasma TAC and the latest findings on dietary modulation of plasma redox status. Finally, the feasibility of the 'TAC concept' as an innovative tool for investigating the association between diet and oxidative stress is discussed.

Keywords: DISEASE; REDOX STATUS; TOTAL ANTIOXIDANT CAPACITY; DIETARY ANTIOXIDANTS

Document Type: Review Article

DOI: http://dx.doi.org/10.1179/135100004225004814

Affiliations: 1: Antioxidant Research Laboratory, Unit of Human Nutrition, National Institute for Food and Nutrition Research, Rome, Italy 2: Human Nutrition Unit, Department of Public Health, University of Parma, Parma, Italy

Publication date: 2004-06-01

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