IngentaConnect Fast Track Article: Common genetic coagulation varian...ic stroke in a casecontrol study

Authors: Susanna Moskau, Kerstin Smolka, Alexander Semmler, Dirk Schweichel, Ursula Harbrecht, Jens Müller, Christoph Pohl, Thomas Klockgether, Michael Linnebank

Abstract:

Objective: Abnormalities in the coagulation pathway are often included in the diagnostic work-up of stroke patients, especially in young adults with cryptogenic stroke. Methods: Three common genetic variants within the coagulation cascade were investigated in 500 control subjects and in 167 patients with ischemic stroke defined by TOAST subclassification. Analysed variants were factor V Leiden, prothrombin 20210G→A and factor XIII Val34Leu. Results: The factor V Leiden mutation was over-represented in patients with cardioembolic stroke for trend, whereas the prothrombin 20210G→A variant and the factor XIII polymorphism Val34Leu were not associated with stroke of any subtype. The three polymorphisms showed no association with stroke in subgroups of patients defined by age (<40, 40–49, 50–59, ࣙ60 years). Discussion: This study suggests that the analysis of prothrombin 20210G→A and factor XIII Val34Leu is not a useful diagnostic procedure in the work-up of ischemic stroke.

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Common genetic coagulation variants are not associated with ischemic stroke in a casecontrol study