Atrophy/hypertrophy cell signaling in muscles of young athletes trained with vibrational-proprioceptive stimulation
Authors: Kern, Helmut; Pelosi, Laura; Coletto, Luisa; Musarò, Antonio; Sandri, Marco; Vogelauer, Michael; Trimmel, Lukas; Cvecka, Jan; Hamar, Dusan; Kovarik, Josef; Löfler, Stefan; Sarabon, Nejc; Protasi, Feliciano; Adami, Nicoletta; Biral, Donatella; Zampieri, Sandra; Carraro, Ugo
Source: Neurological Research, Volume 33, Number 10, December 2011 , pp. 998-1009(12)
Publisher: Maney Publishing
Objective: To compare the effects of isokinetic (ISO-K) and vibrational-proprioceptive (VIB) trainings on muscle mass and strength.
Methods: In 29 ISO-K- or VIB-trained young athletes we evaluated: force, muscle fiber morphometry, and gene expression of muscle atrophy/hypertrophy cell signaling.
Results: VIB training increased the maximal isometric unilateral leg extension force by 48·1%. ISO-K training improved the force by 24·8%. Both improvements were statistically significant (P0·01). The more functional effectiveness of the VIB training in comparison with the ISO-K training was shown by the statistical significance changes only in VIB group in: rate of force development in time segment 0‐50 ms (P<0·001), squat jump (P<0·05) and 30-m acceleration running test (P<0·05). VIB training induced a highly significant increase of mean diameter of fast fiber (+9%, P<0·001), but not of slow muscle fibers (−3%, not significant). No neural cell adhesion molecule-positive (N-CAM+) and embryonic myosin heavy chain-positive (MHC-emb+) myofibers were detected. VIB induced a significant twofold increase (P<0·05) of the skeletal muscle isoform insulin-like growth factor-1 (IGF-1) Ec mRNA. Atrogin-1 and muscle ring finger-1 (MuRF-1) did not change, but myostatin was strongly downregulated after VIB training (P<0·001). Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) expression increased in post-training groups, but only in VIB reached statistical significance (+228%, P<0·05).
Discussion: We demonstrated that both trainings are effective and do not induce muscle damage. Only VIB-trained group showed statistical significance increase of hypertrophy cell signaling pathways (IGF-1Ec and PGC-1α upregulation, and myostatin downregulation) leading to hypertrophy of fast twitch muscle fibers.
Document Type: Original Article
Affiliations: Wilhelminenspital, Wien, Austria
Publication date: December 2011
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- By this author: Kern, Helmut ; Pelosi, Laura ; Coletto, Luisa ; Musarò, Antonio ; Sandri, Marco ; Vogelauer, Michael ; Trimmel, Lukas ; Cvecka, Jan ; Hamar, Dusan ; Kovarik, Josef ; Löfler, Stefan ; Sarabon, Nejc ; Protasi, Feliciano ; Adami, Nicoletta ; Biral, Donatella ; Zampieri, Sandra ; Carraro, Ugo