IngentaConnect Minimum apparent diffusion coefficient for the differential diagn...

Authors: Kikuchi, Toshio¹; Kumabe, Toshihiro¹; Higano, Shuichi²; Watanabe, Mika³; Tominaga, Teiji¹

Source: Neurological Research, Volume 31, Number 10, December 2009 , pp. 1102-1107(6)

Abstract:

Objectives: The utility of apparent diffusion coefficient (ADC) values was evaluated for the differential diagnosis of ganglioglioma.

Methods: Ten consecutive patients, five men and five women, aged from 14 to 67 years, with histologically proven supratentorial gangliogliomas, underwent diffusion-weighted magnetic resonance imaging with echo planar imaging technique. The minimum ADC (minADC) of each tumor was pre-operatively determined from several regions of interest. The minADC of ganglioglioma was compared with that of low- or high-grade astrocytomas (astrocytoma, anaplastic astrocytoma and glioblastoma). Tumor cellularity of gangliogliomas was compared with the minADC.

Results: The mean minADC of the gangliogliomas (1.45 ± 0.20 × 10⁻³ mm²/s) was significantly higher than that of the low- or high-grade astrocytomas. Tumor cellularity of ganglioglioma was inversely correlated with the minADC value.

Discussion: The minADC value reflects in the low tumor cellularity of gangliogliomas and may provide a method for the differential diagnosis of ganglioglioma.

Keywords: APPARENT DIFFUSION COEFFICIENT; DIFFERENTIAL DIAGNOSIS; DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING; GANGLIOGLIOMA; TUMOR CELLULARITY

Document Type: Research article

DOI: 10.1179/174313209X382539

Affiliations: 1: Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan 2: Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan 3: Department of Pathology, Tohoku University Hospital, Aoba-ku, Sendai, Japan

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Minimum apparent diffusion coefficient for the differential diagnosis of ganglioglioma