New laboratory markers in diagnosis of alzheimer dementia

Authors: Mareš, J.¹; Kanovsky, P.¹; Herzig, R.¹; Stejskal, D.²; Vavrouskova, J.²; Hlustik, P.¹; Vranova, H.¹; Burval, S.³; Zapletalova, J.⁴; Pidrman, V.⁵; Obereigneru, R.⁶; Suchy, A.⁶; Vesely, J.⁷; Podivinsky, J.⁸; Urbanek, K.¹

Source: Neurological Research, Volume 31, Number 10, December 2009 , pp. 1056-1059(4)

Publisher: Maney Publishing

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Abstract:

Objectives: The aim of our work was to assess the role of tau protein, beta amyloid and cystatin C in diagnosis of Alzheimer dementia (AD) and other neurodegenerative diseases (NDs).

Methods: The levels of tau protein, beta amyloid and cystatin C were assessed in a set of 79 patients with ND (38 men and 41 women; aged 22-90 years; mean, 61.6 ± 15.6 years) and in a control group of 79 subjects with a healthy central nervous system (38 men and 41 women; aged 20-91 years; mean, 61.5 ± 15.1 years).

Results: When compared with the subjects in the control group, a statistically significant decrease in tau protein levels was found in patients with ND, an increase in tau protein levels in patients with AD and an increase in cystatin C cerebrospinal fluid/serum index in the ND + AD group.

Discussion: Our work only confirmed the previously reported results in part. Although tau protein seems to be a quite reliable marker of AD, the role of beta amyloid in AD diagnosis remains at the least questionable. In the case of cystatin C, our results would seem to confirm the views of certain authors that cystatin C will probably not become a new 'revolutionary' marker contributing to differential diagnostics.

Keywords: ALZHEIMER DEMENTIA; BETA AMYLOID; CYSTATIN C; NEURODEGENERATIVE DISEASES; TAU PROTEIN

Document Type: Research article

DOI: 10.1179/174313209X385536

Affiliations: 1: Department of Neurology, University Hospital, Olomouc, Czech Republic 2: Department of Hospital Sternberk, Sternberk, Czech Republic 3: Department of Radiology, University Hospital, Olomouc, Czech Republic 4: Department of Biometrics, Palacky University Medical School, Olomouc, Czech Republic 5: Department of Psychiatry, University Hospital, Olomouc, Czech Republic 6: Department of Psychology, University Hospital, Olomouc, Czech Republic 7: Department of Pathophysiology, Palacky University Medical School, Olomouc, Czech Republic 8: Department of Neurology Geriatric Medical Institution, Moravský Beroun, Czech Republic

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