Home >> Neurological Research, Volume 31, Number 9

T3 receptors in human pituitary tumors

Authors: Machiavelli, Gloria A.1; Pauni, Micaela2; Heredia Sereno, Gastón M.2; Szijan, Irene1; Basso, Armando3; Burdman, José A.2

Source: Neurological Research, Volume 31, Number 9, November 2009 , pp. 928-930(3)

Publisher: Maney Publishing

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Abstract:

Objective: The purpose of this work was to investigate the synthesis of T3 receptors in human tumors of the anterior pituitary gland, its relationship with the hormone synthesized and/or secreted by the tumor and the post-surgical evolution of the patient.

Methods: Patients were evaluated clinically and by magnetic nuclear resonance to classify the adenoma according to their size. Hormonal concentrations in sera were determined by radioimmunoassay. Immunohistochemistry of the pituitary hormones was performed in the tumors. Tumors were obtained at surgery and immediately frozen in ice, transported to the laboratory and stored at ?70?C. Reverse transcription was performed with purified RNA from the tumors.

Results: Out of 33 pituitary tumors, 29 had RNA for T3 receptors synthesis (88%). They were present in different histological specimens, the tumors were grades 1?4 according to their size, and there was no relationship between the size of the tumor and the presence of T3 receptor RNAs. The post-surgical evolution of the patient was mostly dependent on the size and not on the presence of T3 receptors.

Discussion: The presence of thyroid hormone receptors in pituitary tumors is in line with two important characteristics of these tumors: they are histologically benign and well differentiated.Objective: The purpose of this work was to investigate the synthesis of T3 receptors in human tumors of the anterior pituitary gland, its relationship with the hormone synthesized and/or secreted by the tumor and the post-surgical evolution of the patient.

Methods: Patients were evaluated clinically and by magnetic nuclear resonance to classify the adenoma according to their size. Hormonal concentrations in sera were determined by radioimmunoassay. Immunohistochemistry of the pituitary hormones was performed in the tumors. Tumors were obtained at surgery and immediately frozen in ice, transported to the laboratory and stored at ?70?C. Reverse transcription was performed with purified RNA from the tumors.

Results: Out of 33 pituitary tumors, 29 had RNA for T3 receptors synthesis (88%). They were present in different histological specimens, the tumors were grades 1?4 according to their size, and there was no relationship between the size of the tumor and the presence of T3 receptor RNAs. The post-surgical evolution of the patient was mostly dependent on the size and not on the presence of T3 receptors.

Discussion: The presence of thyroid hormone receptors in pituitary tumors is in line with two important characteristics of these tumors: they are histologically benign and well differentiated.

Keywords: RECEPTOR T3; PITUITARY TUMORS

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/174313209X380955

Affiliations: 1: Cátedra de Genética y Biología Molecular de la Facultad de Farmacia y Bioquímica, Buenous Aires, Argentina 2: Centro de Altos Estudios en Ciencias de la Salud (CAECIS), Universidad Abierta Interamericana, Montes de Oca 745, 1270 Buenos Aires, Argentina 3: Instituto de Neurociencias, Universidad de Buenos Aires, Buenous Aires, Argentina

Publication date: 2009-11-01

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