IngentaConnect High-resolution three-dimensional 3 T magnetic resonance angiogra...

Abstract:

Objective: The standard technique of two-dimensional intra-arterial digital subtraction angiography (2D-DSA) for the imaging of experimental rabbit aneurysms is invasive and has considerable surgical risks. Therefore, minimally invasive techniques ideally providing three-dimensional imaging for intervention planning and follow-up are needed. This study evaluates the feasibility and quality of three-dimensional 3-T magnetic resonance angiography (3D-3T-MRA) and compares 3D-3T-MRA with 2D-DSA in experimental aneurysms in the rabbit.

Method: Three microsurgically created aneurysms in three rabbits were evaluated using 2D-DSA and 3D-3T-MRA. Imaging of the aneurysms was performed 2 weeks after creation using 2D-DSA and contrast-enhanced (CE) MRA. Measurements included aneurysm dome (length and width) and aneurysm neck. Aneurysm volumes were determined using CE-MRA.

Results: The measurements of the aneurysms' dimensions and the evaluation of vicinity vessels with both techniques showed a good correlation. The mean aneurysm length, aneurysm width and neck width measured with DSA (6.9, 4.1 and 2.8 mm, respectively) correlated with the measurements performed in 3D-3T-MRA (6.9, 4 and 2.5 mm, respectively). The mean aneurysm volumes measured with CE-MRA was 46.7 mm³.

Conclusion: 3D-3T CE-MRA is feasible and less invasive and is a safer imaging alternative to DSA for experimental aneurysm. Additionally, aneurysm technique this precise offers the possibility of repetitive 3D aneurysm volumetry for long-term follow-up studies after endovascular aneurysm occlusion.

Keywords: ANEURYSM; EXPERIMENTAL; MRA; ANGIOGRAPHY

Document Type: Research article

DOI: 10.1179/174313209X393979

Affiliations: 1: Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland; Department of Intensive Care Medicine, University Hospital Bern, Bern, Switzerland 2: Department of Intensive Care Medicine, Department of Neurosurgery, University Hospital Bern, Bern, Switzerland 3: Department of Neurosurgery, Kantonsspital Aarau, Department of Intensive Care Medicine, Department of Neurosurgery, University Hospital Bern, Bern, CH-5001 Aarau, Switzerland;, Email: javier.fandino@ksa.ch

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High-resolution three-dimensional 3 T magnetic resonance angiography for the evaluation of experimental aneurysm in the rabbit