Home >> Neurological Research, Volume 31, Number 7

Omental therapy for primary progressive aphasia with tau negative histopathology: 3 year study

Authors: Shankle, William1; Hara, Junko2; Bjornsen, Lynda3; Gade, George4; Leport, Peter5; Ali, Mir5; Kim, Jinho5; Raimo, Maryellen5; Reyes, Linda6; O'Heany, Terence5; Mena, Ismael7

Source: Neurological Research, Volume 31, Number 7, September 2009 , pp. 766-769(4)

Publisher: Maney Publishing

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Abstract:

Objective: Omentum transposition surgery (OT) applied to various neurodegenerative disorders has produced clinically significant improvement, which may be due to omentally-derived factors. To evaluate the clinical effect of left hemisphere OT in a primary progressive aphasia (PPA) patient, 3 year follow-up data were analysed.

Methods: Left hemisphere OT was performed on a 68-year-old male with PPA, characterized by moderate dementia and severe expressive aphasia with relatively preserved comprehension, object recognition and visual-spatial abilities. He was longitudinally assessed with cognitive, functional, behavioral and brain HMPAO SPECT measures pre-OT, at baseline and every 3?6 months for 34 months.

Results: All measures improved above baseline for >20 months and persisted at or above baseline for 34 months. Cortical activity increased by a maximum of 21% underneath transposed omentum and in synaptically connected areas, and persisted in >50% of the cortex for at least 12 months. Subjectively, family members observed improved verbal and non-verbal communication.

Conclusion: OT produced a sustained, beneficial treatment effect in PPA and warrants further clinical and basic research to identify explanatory factors.

Keywords: FRONTAL LOBE DEMENTIA; PRIMARY PROGRESSIVE APHASIA; FRONTOTEMPORAL DEMENTIA; OMENTUM

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/174313209X382511

Affiliations: 1: Fountain Valley Regional Hospital and Medical Center, Fountain Valley, CA, USA; Department of Cognitive Science, University of California at Irvine, Irvine, CA, USA; The Shankle Clinic, Irvine, CA, USA 2: The Shankle Clinic, Irvine, CA, USA 3: Lakewood Regional Medical Center, Lakewood, CA, USA 4: Fountain Valley Regional Hospital and Medical Center, Fountain Valley, CA, USA; Department of Neuroscience, Morton Plant Mease Hospital, Clearwater, FL, USA 5: Fountain Valley Regional Hospital and Medical Center, Fountain Valley, CA, USA 6: Fountain Valley Regional Hospital and Medical Center, Fountain Valley, CA, USA; Cardiology Specialist Medical Group, Inc., Riverside, CA, USA 7: Depto. de Medicina Nuclear, Clínica Las Condes, Santiago, Chile

Publication date: 2009-09-01

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