Authors: Mohammadi, B.¹; Buhr, N.¹; Bigalke, H.²; Krampfl, K.¹; Dengler, R.¹; Kollewe, K.¹

Source: Neurological Research, Volume 31, Number 5, June 2009 , pp. 463-466(4)

Publisher: Maney Publishing

Abstract:

Objective: Cervical dystonia (CD) is the most common form of adult-onset focal dystonia, and botulinum toxin A (BoNT-A) has become the first-line treatment for this condition.

Methods: In this work, we present data of 207 CD patients treated with BoNT-A for 6.7 ± 3.5 years. One hundred and sixty-three patients were treated with Dysport (mean dose, 389 ± 144 U) and 44 with Botox (mean dose, 145 ± 44 U).

Results: The mean clinical benefit, based on a 0–3 scale (0=no effect, 1=slight, 2=moderate and 3=marked improvement) was similar for Dysport (2.5 ± 0.3) and Botox (2.2 ± 0.4). Adverse events were mild and similar for both products. Fewer than 2% of the patients developed neutralizing antibodies.

Discussion: These data confirm the efficacy and safety of BoNT-A treatment in CD over an extended period of up to 14 years.

Keywords: CERVICAL DYSTONIA; BOTULINUM TOXIN; LONG-TERM FOLLOW-UP

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/174313209X405137

Affiliations: 1: Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany 2: Department of Toxicology, Hannover Medical School, Hannover, Germany

Publication date: 2009-06-01

More about this publication?

• Authors wishing to cite fast track papers should give the journal name and the article DOI. This will enable reference linking via CrossRef and allow forward and backward citation tracking systems to associate the fast track citation with the final journal reference.

• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Information for Advertisers
• Terms & Conditions
• Virtual Maney - Stroke
• Top articles
• Health Sciences Spotlight
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Neurology & Psychiatry
• By this author: Mohammadi, B. ;  Buhr, N. ;  Bigalke, H. ;  Krampfl, K. ;  Dengler, R. ;  Kollewe, K.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers