IngentaConnect Angiotensin II receptor 1 involved in the central pressor respons...

Authors: Lu, Yang¹; Chen, Jianguang²; Yin, Xiaohua³; Zhao, Hua¹

Source: Neurological Research, Volume 31, Number 4, May 2009 , pp. 420-424(5)

Abstract:

Objective: To investigate the possible participation of angiotensin II receptor 1 (AT₁ receptor) in pressor response induced by IL-1β in the paraventricular nucleus (PVN) of hypothalamus.

Methods: The experiments were performed on adult Wistar rats. Mean arterial pressure (MAP) were recorded during microinjection of different doses of IL-1β, IL-1β together with Losartan, an AT1 receptor antagonist, or Ang II pre-treated with IL-1β into PVN. Rats microinjected with saline were served as controls in all experiments.

Results: Microinjection of IL-1β (0.1 or 0.2 ng) resulted in increases in blood pressure in a dose-dependent manner, and the pressor effect caused by administration of IL-1β (0.2 ng) could be attenuated by pre-treatment with AT₁ receptor antagonist (100 ng Losartan). A subpressor dose of IL-1β (0.05 ng) could augment the pressor response induced by microinjection of Ang II (10 ng).

Discussion: The present results provide support that central infusion of IL-1β increases blood pressure and the pressor response requires stimulation of AT₁ receptors. It is also shown that IL-1β has the effect of increasing the magnitude of pressor response induced by Ang II in PVN.

Keywords: ANGIOTENSIN II; AT1 RECEPTOR; INTERLEUKIN-1 BETA; LOSARTAN; PARAVENTRICULAR NUCLEUS

Document Type: Research article

DOI: 10.1179/174313208X353677

Affiliations: 1: Department of Physiology, School of Basic Medical Sciences, Jilin University, Jilin, China 2: Department of Physiology, School of Basic Medical Sciences, Beihua University, Jilin, China 3: Department of Nuclear Medicine, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Angiotensin II receptor 1 involved in the central pressor response induced by interleukin-1 beta in the paraventricular nucleus