Authors: Liu, Ya-Ling; Guo, Yan-Su; Xu, Lei; Wu, Shu-Yu; Wu, Dong-Xia; Yang, Cheng; Li, Chun-Yan

Source: Neurological Research, Volume 30, Number 9, November 2008 , pp. 990-994(5)

Publisher: Maney Publishing

Abstract:

Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder. A pathologic hallmark of ALS is accumulation of neurofilaments in proximal axons of affected motor neurones. As the neurofilaments involved in immune-mediated spinal cord ventral horn motor neuron degeneration and loss, we developed immune-mediated motor neuron injury animal model by inoculating Lewis rats with swine spinal cord homogenate and investigated the ultrastructural features of neurofilament accumulation using transmission electron microscopy. Our results showed that there was aberrant accumulation of neurofilaments in perikarya and processes of remaining motor neurons in recipient animals, which is similar to those observed in ALS patients. These findings suggest that immune-mediated motor neuron injury may share a common pathogenesis with ALS.

Keywords: ULTRASTRUCTURAL; MOTOR NEURON; AMYOTROPHIC LATERAL SCLEROSIS; NEUROFILAMENTS ACCUMULATION; IMMUNE-MEDIATED

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/016164108X323780

Affiliations: Department of Neurology, Second Hospital of Hebei Medical University, 215 He-Ping West Road, Shijiazhuang 050000, China

Publication date: 2008-11-01

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