IngentaConnect Vasospasm after SAH due to aneurysm rupture of the anterior circl...

Authors: Fontanella, MarcoMaria¹; Valfrè, Walter²; Benech, Franco¹; Carlino, Christian¹; Garbossa, Diego¹; Ferrio, MariaFederica³; Perez, Rosa¹; Berardino, Maurizio⁴; Bradac, GianniBoris³; Ducati, Alessandro¹

Source: Neurological Research, Volume 30, Number 3, April 2008 , pp. 256-261(6)

Publisher: Maney Publishing

Abstract:

Objective: The aim of this study was to verify the presence of angiographic vasospasm in patients with transcranial Doppler (TCD) of high velocities after subarachnoid hemorrhage (SAH).

Methods: Seven hundred and eighty-six cases admitted within 48 hours after SAH due to the rupture of anterior circulation aneurysm, were prospectively studied with TCD. In cases of TCD velocities higher than 120 cm/s (TCD vasospasm), the patient underwent a control angiography. Hunt-Hess and Fisher's grade on admission CT and location of the aneurysm were related to occurrence of TCD vasospasm. The increase in TCD velocities within 24 hours was calculated and related to the presence of cerebral ischemia on discharge CT, considering three groups of patients: Group A with an increase in velocities higher than 60%, Group B with an increase in velocities between 30 and 60%, and Group C with an increase in velocities lower than 30%.

Results: TCD vasospasm was observed in 216 patients (27%). In 97% of patients with TCD vasospasm on middle cerebral artery (MCA) and in 71% with TCD vasospasm on anterior cerebral artery (ACA), control angiography confirmed the vasospasm, with a significant lower diagnostic TCD predictivity of ACA spasm (χ²=28.204, p=0.000). The overall positive predictive value of TCD was 89%. There was no significant correlation of TCD vasospasm with clinical status on admission and location of the aneurysm, but a significant correlation between occurrence of TCD vasospasm and Fisher's grade (χ²=15.470, p=0.002) and between the increase rate in TCD velocities and cerebral ischemia (χ²=56.564, p=0.000).

Conclusion: Our study shows a good correlation between TCD and angiography to detect vasospasm on MCA, but the correlation is low for ACA. TCD alone cannot discriminate different hemodynamic pathways after SAH.

Keywords: CEREBRAL ANGIOGRAPHY; CEREBRAL ISCHEMIA; HYPEREMIA; SUBARACHNOID HEMORRHAGE; TRANSCRANIAL DOPPLER; VASOSPASM

Document Type: Research article

DOI: 10.1179/016164107X229939

Affiliations: 1: Division of Neurosurgery, Department of Neuroscience, University of Torino, Torino, Italy 2: Division of Neurology II, Department of Neuroscience, University of Torino, Torino, Italy 3: Division of Neuroradiology, Department of Neuroscience, University of Torino, Torino, Italy 4: Division of Neuroanaesthesiology, Department of Neuroscience, University of Torino, Torino, Italy

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Vasospasm after SAH due to aneurysm rupture of the anterior circle of Willis: value of TCD monitoring