Acupuncture decreases ischemia-induced apoptosis and cell proliferation in dentate gyrus of gerbils
Source: Neurological Research, Volume 29, Supplement 1, February 2007 , pp. 23-27(5)
Publisher: Maney Publishing
Abstract:Background: Acupuncture has been used for the enhancement of functional recovery from various disorders. In the present study, the effect of acupuncture on the apoptosis and new cell proliferation in the hippocampal dentate gyrus of gerbils (n = 25) following transient global ischemia was investigated.
Methods: To determine the level of apoptosis and cell proliferation, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay and immunohistochemistry for 5-bromo-2′-deoxyuridine (BrdU) were employed respectively.
Results: In the dentate gyrus of ischemic gerbils, the number of both TUNEL- and BrdU-positive cells (66.01 ± 2.45/mm2 and 514.38 ± 44.90/mm2) was significantly increased compared to that of the sham-operated gerbils (11.25 ± 1.85/mm2 and 111.47 ± 10.95/mm2). Among the acupuncture (ST36, LI4 or non-acupoint) treated groups, ST36 acupoint treated group showed the most potent apoptosis (20.52 ± 2.40/mm2) and proliferation (159.38 ± 24.05/mm2) suppressive effects (∼70% decreases in both apoptosis and cell proliferation).
Conclusion: These results may suggest that acupuncture treatment alleviates ischemia-induced apoptosis and presents possible therapeutic potentials in the recovery from ischemic cerebral injury.
Document Type: Research Article
Affiliations: 1: College of Korean Medicine, Semyung University, Jechon 390-711, Korea 2: Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Korea 3: Department of Food and Nutrition in Oriental Medicine, Semyung University, Jechon 390-711, Korea 4: Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-701, Korea 5: Department of Medical Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea 6: Department of Meridian and Acupuncture, College of Medicine, Kyung Hee University, Seoul 130-701, Korea
Publication date: 2007-02-01
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