Authors: Yu, Hsiang-Yu¹; Chen, Jen-Tse²; Wu, Zin-An¹; Yeh, Tzu-Chen³; Ho, Low-Tone⁴; Lin, Yung-Yang⁵

Source: Neurological Research, Volume 29, Number 5, July 2007 , pp. 517-522(6)

Publisher: Maney Publishing

Abstract:

Objective: To evaluate whether the side of stimulated ear affects the hemispheric asymmetry of auditory evoked cortical activations.

Methods: Using a whole-head neuromagnetometer, we recorded neuromagnetic ?100 ms responses (N100m) in 21 healthy right-handers to 100 ms 1 kHz tones delivered alternatively to left and right ear.

Results: Although the peak latencies of N100m were shorter in contralateral than in ipsilateral hemisphere, the difference was significant only for the left ear stimulation. Based on the relative N100m amplitudes across hemispheres, the laterality evaluation showed a rightward predominance of N100m activation to tone stimuli, but the lateralization toward the right hemisphere was more apparent by the left than by the right ear stimulation (laterality index: ?0.27 versus ?0.10, p=0.008). Within the right hemisphere, the N100m was 2?4 mm more posterior for left ear than for right ear stimulation.

Conclusions: The hemispheric asymmetry in auditory processing depends on the side of the stimulated ear. The more anterior localization of right N100m responses to ipsilateral than to contralateral ear stimulation suggests that there might be differential neuronal populations in the right hemisphere for processing spatially different auditory inputs.

Keywords: AUDITORY CORTICAL RESPONSES; MAGNETOENCEPHALOGRAPHY; N100M; HEMISPHERIC ASYMMETRY; HUMAN

Document Type: Research Article

DOI: http://dx.doi.org/10.1179/016164107X164157

Affiliations: 1: Department of Neurology, National Yang-Ming University, Taipei, Taiwan; Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan 2: Department of Neurology, National Yang-Ming University, Taipei, Taiwan; Department of Neurology, Cathay General Hospital, Taipei, Taiwan 3: Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan 4: Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Physiology, National Yang-Ming University, Taipei, Taiwan 5: Department of Neurology, National Yang-Ming University, Taipei, Taiwan; Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Physiology, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

Publication date: 2007-07-01

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